The Sylvester Comprehensive Cancer Center at University of Miami currently has an opening in our NIH-funded post-doctoral T32 Cancer Epigenetics Training Grant. A post-doctoral position is available for a research project studying the role of Polycomb complexes in cancer.
The laboratory of Dr. Lluis Moreyfocuses on studying the contribution of Polycomb group complexes in dictating cell fate determination of human stem cells and cancer. We recently showed that the Polycomb Repressive Complex 1 (PRC1) core subunit RING1B is amplified in multiple cancer types. Mechanistically, RING1B is recruited to active enhancers in breast cancer, leukemia and hepatocellular carcinoma, indicating a general and unexpected RING1B function in regulating oncogenic pathways in multiple cancer types (Chan et al. Nature Comm, 2018). Our previous work demonstrated that pluripotency and differentiation of embryonic stem cells (ESCs) is regulated by different Cbx-associated PRC1 complexes with unique functions (Morey et al. Cell Stem Cell, 2012; Morey et al. Cell Reports, 2013; Santanach et al. Nature Comm, 2017). Furthermore, we have identified that PCGF2 uniquely regulates PRC1 to specify mesoderm cell fate (cardiac and cartilage) in embryonic stem cells (Morey et al. Cell Stem Cell, 2015).
We are seeking an independent and highly creative postdoctoral fellow with experience in molecular biology, biochemistry, and/or structural biology. Familiarity with programming languages is important. Prior experience in epigenetics is preferred but not required. It is expected that the candidate will have the ability design experiments, collect and tabulate data, publish and present results, as well as to participate in the training of graduate and rotation students in a research laboratory setting. The project will include genome-wide studies of enhancer-promoter interactions, genome-editing, biochemistry and mouse models.
Ph.D. in molecular biology, cancer biology or related fields. Experience in a research laboratory setting. Evidence of scholarly ability (record of publication in peer reviewed journals, etc.). Ability to communicate in written and spoken English is absolutely required. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work.
Two reference letters, one of them from the Ph.D. advisor, are required.
Please note, Cancer Epigenetics T32 Training Grant Program applicants must meet the following criteria to be considered:
· Must be a US Citizens or Permanent Resident or a non-citizen national, or must have been lawfully admitted for permanent residence and possess an Alien Registration Receipt Card (1-151 or 1-551) or some other verification of legal admission as a permanent resident.
· Must be within 4 years of obtaining their Ph.D.
· M.D.s must be within 4 years of their residency or fellowship
· Candidates must be available for a Full-time, 12-month appointment and agree to undertake a minimum of two years of research, research training, or comparable experiences from the time of appointment.
· Must be accepted to a T32 Mentor’s lab
How to apply:Please submit CV, and contact information for 2 references combined into one PDF file by email to Dr. Lluis Morey email: firstname.lastname@example.org